EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.22 | 1-(2,2,3,3,3-pentafluoropropyl)piperidin-4-yl 5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxoimidazolidin-1-yl)-2,3-dihydro-1H-indole-1-carboxylate | ex hibits more than 100fold selectivity over human MGAT3, human DGAT1, and human DGAT2 | Homo sapiens | |
2.3.1.22 | 1-(2,2,3,3,3-pentafluoropropyl)piperidin-4-yl 5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxoimidazolidin-1-yl)-2,3-dihydro-1H-indole-1-carboxylate | - |
Mus musculus | |
2.3.1.22 | 1-([1,1'-biphenyl]-4-yl)-N-(2,4-difluorophenyl)-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide | ex hibits more than 100fold selectivity over human MGAT3, human DGAT1, and human DGAT2 | Homo sapiens | |
2.3.1.22 | 1-([1,1'-biphenyl]-4-yl)-N-(2,4-difluorophenyl)-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide | - |
Mus musculus | |
2.3.1.22 | 2-[5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl)pyrimidine-5-carboxamide | ex hibits more than 100fold selectivity over human MGAT3, human DGAT1, and human DGAT2 | Homo sapiens | |
2.3.1.22 | 2-[5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl)pyrimidine-5-carboxamide | - |
Mus musculus | |
2.3.1.22 | benzyl 2-[5-[(2,4-difluorophenyl)sulfamoyl]-7-(5-oxopyrazolidin-1-yl)-2,3-dihydro-1H-indol-1-yl]pyrimidine-5-carboxylate | ex hibits more than 100fold selectivity over human MGAT3, human DGAT1, and human DGAT2 | Homo sapiens | |
2.3.1.22 | benzyl 2-[5-[(2,4-difluorophenyl)sulfamoyl]-7-(5-oxopyrazolidin-1-yl)-2,3-dihydro-1H-indol-1-yl]pyrimidine-5-carboxylate | - |
Mus musculus | |
2.3.1.22 | N-(2,4-difluorophenyl)-7-(2-oxopyrrolidin-1-yl)-1-phenyl-2,3-dihydro-1H-indole-5-sulfonamide | ex hibits more than 100fold selectivity over human MGAT3, human DGAT1, and human DGAT2 | Homo sapiens | |
2.3.1.22 | N-(2,4-difluorophenyl)-7-(2-oxopyrrolidin-1-yl)-1-phenyl-2,3-dihydro-1H-indole-5-sulfonamide | - |
Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.22 | Homo sapiens | Q3SYC2 | - |
- |
2.3.1.22 | Mus musculus | Q80W94 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.22 | intestine | - |
Homo sapiens | - |
2.3.1.22 | intestine | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.22 | oleoyl-CoA + 2-oleoylglycerol | - |
Homo sapiens | CoA + 1,2-dioleoylglycerol | - |
? | |
2.3.1.22 | oleoyl-CoA + 2-oleoylglycerol | - |
Mus musculus | CoA + 1,2-dioleoylglycerol | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.22 | 0.0000006 | - |
pH 7.4, 23°C | Mus musculus | N-(2,4-difluorophenyl)-7-(2-oxopyrrolidin-1-yl)-1-phenyl-2,3-dihydro-1H-indole-5-sulfonamide | |
2.3.1.22 | 0.0000011 | - |
pH 7.4, 23°C | Mus musculus | benzyl 2-[5-[(2,4-difluorophenyl)sulfamoyl]-7-(5-oxopyrazolidin-1-yl)-2,3-dihydro-1H-indol-1-yl]pyrimidine-5-carboxylate | |
2.3.1.22 | 0.0000014 | - |
pH 7.4, 23°C | Homo sapiens | 1-([1,1'-biphenyl]-4-yl)-N-(2,4-difluorophenyl)-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide | |
2.3.1.22 | 0.0000016 | - |
pH 7.4, 23°C | Mus musculus | 1-([1,1'-biphenyl]-4-yl)-N-(2,4-difluorophenyl)-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide | |
2.3.1.22 | 0.0000019 | - |
pH 7.4, 23°C | Mus musculus | 2-[5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl)pyrimidine-5-carboxamide | |
2.3.1.22 | 0.0000032 | - |
pH 7.4, 23°C | Homo sapiens | N-(2,4-difluorophenyl)-7-(2-oxopyrrolidin-1-yl)-1-phenyl-2,3-dihydro-1H-indole-5-sulfonamide | |
2.3.1.22 | 0.0000034 | - |
pH 7.4, 23°C | Homo sapiens | benzyl 2-[5-[(2,4-difluorophenyl)sulfamoyl]-7-(5-oxopyrazolidin-1-yl)-2,3-dihydro-1H-indol-1-yl]pyrimidine-5-carboxylate | |
2.3.1.22 | 0.0000038 | - |
pH 7.4, 23°C | Mus musculus | 1-(2,2,3,3,3-pentafluoropropyl)piperidin-4-yl 5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxoimidazolidin-1-yl)-2,3-dihydro-1H-indole-1-carboxylate | |
2.3.1.22 | 0.0000051 | - |
pH 7.4, 23°C | Homo sapiens | 2-[5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl)pyrimidine-5-carboxamide | |
2.3.1.22 | 0.0000067 | - |
pH 7.4, 23°C | Homo sapiens | 1-(2,2,3,3,3-pentafluoropropyl)piperidin-4-yl 5-[(2,4-difluorophenyl)sulfamoyl]-7-(2-oxoimidazolidin-1-yl)-2,3-dihydro-1H-indole-1-carboxylate |